Glantreo Innovative Scientific Solutions https://glantreo.com/ Innovative scientific solutions to solve cross-disciplinary issues. Mon, 11 Dec 2023 09:36:30 +0000 en-GB hourly 1 https://wordpress.org/?v=6.4.3 https://glantreo.com/wp-content/uploads/2020/03/Logo-G-100x100.jpg Glantreo Innovative Scientific Solutions https://glantreo.com/ 32 32 Glantreo awarded extended scope to ISO 9001:2015 https://glantreo.com/glantreo-iso-90012015-recertified-2023/ Thu, 14 Sep 2023 10:39:14 +0000 https://glantreo.com/?p=14032 Glantreo have continued to enhance the assurance they can give their clients from a quality perspective with an extension to the scope of their ISO 9001:2015 certification.

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Glantreo has been ISO 9001:2015 recertified:

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Magnetic Silica Powder Material Safety Data Sheet – Glantreo https://glantreo.com/magnetic-silica-powder-material-safety-data-sheet-glantreo-2/ Wed, 24 May 2023 13:42:05 +0000 https://glantreo.com/?p=16814 MSDS for Glantreo Silica Powder

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Magnetic Silica Powder Material Safety Data Sheet – Glantreo

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Silica Powder Material Safety Data Sheet – Glantreo https://glantreo.com/silica-powder-material-safety-data-sheet-glantreo/ Wed, 24 May 2023 11:42:24 +0000 https://glantreo.com/?p=16811 MSDS for Glantreo Silica Powder

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Silica Powder Material Safety Data Sheet – Glantreo

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Glantreo Chromatography Slide Deck https://glantreo.com/chroma-slidedeck/ Fri, 24 Mar 2023 11:54:26 +0000 https://glantreo.com/?p=16729 Glantreo's has an extensive capability in Chromatography. This slide decks seeks to explain to potential partners, customers and the general chromatography community the range and depth of this capability.

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Glantreo Chromatography Slide Deck

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SOLAS Silica Particles – Technical Data Sheet https://glantreo.com/solas-materials-technical-data-sheet/ Tue, 07 Feb 2023 19:16:21 +0000 https://glantreo.com/?p=16651 The post SOLAS Silica Particles – Technical Data Sheet appeared first on Glantreo Innovative Scientific Solutions.

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SOLAS Silica Particles – Technical Data Sheet

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SOLAD Protein A Column – Technical Data Sheet https://glantreo.com/solad-protein-a-column-tds/ Fri, 03 Feb 2023 16:22:36 +0000 https://glantreo.com/?p=16644

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SOLAD Protein A Column – Technical Data Sheet

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Glantreo launch new SOLAD Protein A column for mAb Analysis https://glantreo.com/solad-protein-a-for-mab-analysis/ Thu, 02 Feb 2023 14:22:50 +0000 https://glantreo.com/?p=16596 The SOLAD™ Protein-A column combines a 10µm sized SOLAD particle with recombinant Protein A ligand through proprietary cutting-edge bonding technology. The result being a hydrophilic resin surface with a high pH stability and a rugged and reproducible column. The column offers superior efficiency and resolution, without analyte carryover.

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Introduction

In monoclonal antibody (mAb) manufacturing, accurate antibody titre determination and monitoring are crucial for clonal selection, optimisation of expression rates, process control and scale-up. For accurate antibody titre quantification, Protein-A Affinity HPLC offers excellent reproducibility, robustness and precision over ELISA-based assays.

The SOLAD™ Protein-A is a novel affinity HPLC column, based on the next-gen SOLAD™ platform technology, for quick separation and robust quantification of various antibodies. It provides rapid, accurate titre analysis with linearity across a wide concentration range, without any carryover.

SEM of SOLAD Particles (2500x magnified)

Highlights

❖ Wide dynamic range

❖ Fast Analysis

❖ High sensitivity & specificity for mAbs

❖ Long lifetime

SEM of SOLAD Particles (10000x magnified)

SOLAD Protein-A Particles zoomed

Column Technology

SOLAD™ is a proprietary product range of highly monodisperse, spherical, durable and reproducible non-porous silica particles manufactured by Glantreo. For protein and antibody analysis, SOLAD™ offers excellent mechanical and chemical stability, with minimal fouling and non-specific adsorption, compared to porous silica and polymeric particles.

The SOLAD™ Protein-A column combines a 10µm sized SOLAD particle with recombinant Protein A ligand through proprietary cutting-edge bonding technology. The result being a hydrophilic resin surface with a high pH stability and a rugged and reproducible column.  The column offers superior efficiency and resolution, without analyte carryover.

The SOLAD™ Protein-A column can accurately measure mAb titres at various phases of development due to its high loading capacity and excellent repeatability. This column is also suitable for small-scale purification of mAbs for initial characterisation due to its reduced Protein A leaching. The column is available in PEEK and Bioinert Stainless Steel column hardware in various dimensions.

SOLAD Protein A Columns

SOLAD Protein-A Column PDS

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Want to know more about our SOLAD range of Columns?

Go to the Product Page.

Technical Specifications and Applications of SOLAD Protein-A Column

Rapid separation of IgG from Impurities (Fig. 1)

Chromatographic Conditions
Column: 4mm x 50 mm PEEK, Binding buffer (A): 50 mM Sodium Phosphate pH 7.4, Elution buffer (B): 50 mM Sodium Phosphate pH 2.5, Gradient: 0%B: 0-0.5 min, 100%B: 0.5-1.1 min, 0%B: 1.1-4 min, Flow rate: 2 mL/min, Detection: UV @ 280 nm, Temperature: 25 C, Sample: 20 µL cell culture supernatant containing mAb
Rapid separation of IgG from impurities

Figure 1 depicts a 20 μL injection of mAb feedstock onto the SOLADTM Protein A column. The proprietary column technology yields sharp, concentrated peaks and fast, efficient elution.

Wide Dynamic Range (Fig. 2)

Wide Dynamic Range

As can be seen in Figure 2, SOLADTM Protein-A delivers accurate titre measurement with linearity, with a dynamic loading capacity in excess of 300 µg.

Flexible Flow Rates (Fig. 3)

Flexible Range of Flow Rates

The SOLADTM Protein-A column can be used from flow rates upto 2.5 mL/min, as seen in Figure 3. This allows fast separation of antibodies without loss of efficiency.

Features of SOLAD Column

SOLAD Protein-A Column PDS

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Go to the Product Page.

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Selenium Nanoparticles Slide Deck https://glantreo.com/senp-deck/ Thu, 19 Jan 2023 13:38:34 +0000 https://glantreo.com/?p=16574 The post Selenium Nanoparticles Slide Deck appeared first on Glantreo Innovative Scientific Solutions.

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Selenium Nanoparticles for LFA – Slide Deck

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Glantreo collaborate with Marama Labs to quantify brightness of Selenium Nanoparticles https://glantreo.com/senp-colour-brightness/ Thu, 12 Jan 2023 21:22:20 +0000 https://glantreo.com/?p=16545 Glantreo’s Selenium Nanoparticles (SeNP) combine large surface area with high colour quality to create a more visible particle, producing a visible line at low concentrations of antigens, for a more sensitive lateral flow assay. Marama Labs CloudSpec device was able to determine Glantreo SeNP were up to 37% more visible than industry standard 40nm AuNP.

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Selenium Nanoparticles (SeNP) for lateral flow assays 

The bright red colour of large selenium colloid solutions makes them ideal for use as staining reagents to label low concentrations targets in immunoassays. Glantreo’s Selenium nanoparticles (SeNP) offer an alternative to gold nanoparticles (AuNP) lateral flow antigen (LFA) tests.

Brighter particles – more sensitive assays 

Glantreo’s Selenium Nanoparticles (SeNP) combine large surface area with high colour quality to create a more visible particle, producing a visible line at low concentrations of antigens, for a more sensitive lateral flow assay. Marama Labs CloudSpecTM device was able to determine Glantreo SeNP were up to 37% more visible than industry standard 40nm AuNP.

SeNP Unique Physio-Optical Properties

When white light hits an object, how wavelengths interact determines the colour seen. A simplified way of measuring and describing the visibility of a solution is by measuring its Extinction optical density (OD) by UV-Vis. Extinction OD is a sum of the spectra for light absorbed and scattered by an object. However, unlike smaller nanoparticles where colour is mostly governed by wavelengths absorbed, a considerable amount of the Extinction OD of large SeNP comes from scattered light, which makes it difficult to measure the colour that can be seen by eye.  To analyse the chromacity, and therefore colour quality of our SeNP, we used a MaramaLabs CloudSpecTM device to quantify the spectral components of our nanoparticles.

Method

The optical properties of Glantreo’s SeNP were evaluated using the CloudSpecTM UV-Vis from MaramaLabs (New Zealand). This instrument uses an integrating sphere to measure both extinction and absorption spectra of samples, producing results in optical density normalized to a path length of 1 cm. The scattering spectrum can, therefore, be deduced from the difference between extinction and absorption spectra.

CloudSpec UV-Vis

Results

CloudSpecTM analysis shows SeNP have a stronger per-particle absorbance than AuNP, which increases with decreasing particle size, making SeNP more visible at lower concentrations. Furthermore, the unique scattering spectra indicate the presence of strong >600nm optical resonances, which create opportunities for more sensitive device configurations. Due to the strength of the scattering contributions to the visibility of these particles, determining the absorbance spectrum from a more traditional, extinction-only spectrophotometer would not have been possible. Representations of the differences in colour and size of different nanoparticles are shown below:

CloudSpec Results

SeNP for LFA – Advantages

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NOMAD – EU consortium for smart dental implants https://glantreo.com/nomad-glantreo/ Thu, 05 Jan 2023 14:10:59 +0000 https://glantreo.com/?p=16820 The SOLAD™ Protein-A column combines a 10µm sized SOLAD particle with recombinant Protein A ligand through proprietary cutting-edge bonding technology. The result being a hydrophilic resin surface with a high pH stability and a rugged and reproducible column. The column offers superior efficiency and resolution, without analyte carryover.

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Glantreo in NOMAD; Innovation for smart dental implants

Glantreo is pleased to announce they are  a key partner in the NOMAD consortium. This EU-funded research and innovation collaborative project is aimed at developing the next generation of dental implants that can prevent peri-implant diseases. Scientists and dental specialists from 10 organizations in 7 European countries have joined forces to tackle the increasing socio-economic burden associated with these diseases.

NOMAD - Creating Smart Dental Solutions

We are excited to partner with world-class companies and research groups  working on smart materials to innovate in the implants space. At present, out of patients receiving dental implants, 43% develop peri-implant mucositis and 22% peri-implantitis, diseases that are painful and reduce implant efficacy. By bringing together specialists in biomaterial, nanomaterials, dentistry and microbiology, NOMAD will create the next generation of dental implants. 

Glantreo is a leading technology company specialising in advanced materials for chromatography, lateral flow assays, biosensors and innovative drug-delivery nanoparticles. In the NOMAD project, Glantreo’s expertise in nanoparticle synthesis and functionalisation is being utilized to develop smart biomaterials for dental implants. Learn more about Glantreo’s cutting-edge solutions for drug delivery :

Want to know more about our mesoporous range of silica materials? Or the NOMAD project?

Click below:

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